Detalles de la búsqueda
1.
Identification of a novel histone H2A mono-ubiquitination-inhibiting cell-active small molecule.
Bioorg Med Chem Lett
; 105: 129759, 2024 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38636717
2.
Structural optimization of a lysine demethylase 5 inhibitor for improvement of its cellular activity.
Bioorg Med Chem
; 98: 117579, 2024 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38168630
3.
Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells.
Bioorg Med Chem
; 100: 117632, 2024 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38340642
4.
A Structure-Activity Relationship Study of SNAIL1 Peptides as Inhibitors of Lysine-Specific Demethylase 1.
Chem Pharm Bull (Tokyo)
; 72(2): 155-160, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38296557
5.
Identification of a Histone Deacetylase 8 Inhibitor through Drug Screenings Based on Machine Learning.
Chem Pharm Bull (Tokyo)
; 72(2): 173-178, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38296560
6.
Origin of the kinetic HDAC2-selectivity of an HDAC inhibitor.
J Comput Chem
; 44(18): 1604-1609, 2023 07 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37074817
7.
A Novel HDAC1-Selective Inhibitor Attenuates Autoimmune Arthritis by Inhibiting Inflammatory Cytokine Production.
Biol Pharm Bull
; 45(9): 1364-1372, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36047206
8.
Identification of Novel Histone Deacetylase 6-Selective Inhibitors Bearing 3,3,3-Trifluorolactic Amide (TFLAM) Motif as a Zinc Binding Group.
Chembiochem
; 22(22): 3158-3163, 2021 11 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-34224197
9.
Metabolic-Pathway-Oriented Screening Targeting S-Adenosyl-l-methionine Reveals the Epigenetic Remodeling Activities of Naturally Occurring Catechols.
J Am Chem Soc
; 142(1): 21-26, 2020 01 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31869215
10.
Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor.
Bioorg Chem
; 94: 103403, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31711765
11.
Drug Discovery Researches on Modulators of Lysine-Modifying Enzymes Based on Strategic Chemistry Approaches.
Chem Pharm Bull (Tokyo)
; 68(1): 34-45, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-31902900
12.
Identification of ortho-hydroxy anilide as a novel scaffold for lysine demethylase 5 inhibitors.
Bioorg Med Chem Lett
; 29(10): 1173-1176, 2019 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30928196
13.
Identification of novel lysine demethylase 5-selective inhibitors by inhibitor-based fragment merging strategy.
Bioorg Med Chem
; 27(6): 1119-1129, 2019 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30745098
14.
Design, Synthesis, and Biological Evaluation of a Conjugate of 5-Fluorouracil and an LSD1 Inhibitor.
Chem Pharm Bull (Tokyo)
; 67(3): 192-195, 2019 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30369513
15.
Chemical Protein Degradation Approach and its Application to Epigenetic Targets.
Chem Rec
; 18(12): 1681-1700, 2018 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-29893461
16.
Design, synthesis, and biological evaluation of novel ubiquitin-activating enzyme inhibitors.
Bioorg Med Chem Lett
; 28(16): 2723-2727, 2018 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29548576
17.
Histone H3 peptides incorporating modified lysine residues as lysine-specific demethylase 1 inhibitors.
Bioorg Med Chem Lett
; 28(2): 167-169, 2018 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29198865
18.
Design, synthesis and evaluation of γ-turn mimetics as LSD1-selective inhibitors.
Bioorg Med Chem
; 26(3): 775-785, 2018 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29331452
19.
Computational analysis for selectivity of histone deacetylase inhibitor by replica-exchange umbrella sampling molecular dynamics simulations.
J Chem Phys
; 148(12): 125102, 2018 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-29604890
20.
Design, Synthesis, and In Vitro Evaluation of Novel Histone H3 Peptide-Based LSD1 Inactivators Incorporating α,α-Disubstituted Amino Acids with γ-Turn-Inducing Structures.
Molecules
; 23(5)2018 05 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29734782